SITES ON NEPHROLOGY
SITES ON NEPHROLOGY
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EntreMed announced that Endostatin and a related drug, Angiostatin were shown to have significant tumor suppression results in trials with mice. The drugs work by turning off the blood supply systems to targeted tumors. Angiostatin and Endostatin proteins were discovered by Judah Folkman, a Harvard University cancer researcher who is also a cancer specialist at Children's Hospital in Boston. |
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The key articles written by Dr. Folkman and his associates are in the scientific journals NATURE and CELL.
The citations for their articles are: Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Boehm T, Folkman J, Browder T, O'Reilly MS. Nature; 390(6658):404-7 1997 If you are serious about understanding the significance and potential of Dr. Folkman's breakthrough discovery, you owe it to yourself to get these two key (professional) reference book in the area of bood vessel formation and cancer. Tumour Angiogenesis, by Roy Bicknell (Editor), Claire E. Lewis (Editor), Napoleone Ferrara (Editor) Regulation of Angiogenesis (Experientia Supplementum, Vol 79),I.D. Goldberg (Editor), E.M. Rosen (Editor) Table of Contents Introduction By I. D. Goldberg, E. M. Rosen Angiogenesis and angiogenesis inhibition: An overview By J. Folkman Role of the macrophage in angiogenesis-dependent diseases By P. J. Polverini Angiogenesis in human gliomas: Prognostic and therapeutic implications By J. P. Johnson Regulation of angiogenesis in malignant gliomas By C. Guerin, J. Laterra Lymphangiogenesis: Mechanisms, significance and clinical implications By M. H. Witte, et al. Angiogenesis as a biologic and prognostic indicator in human breast carcinoma By K. Engels, et al. Fibroblast growth factors as angiogenesis factors: New insights into their mechanism of action By S. Klein, et al. Regulation of angiogenesis by scatter factor By E. M. Rosen, I. D. Goldberg Vascular endothelial growth factor: Basic biology and clinical implications By N. Ferrara Vascular permeability factor/vascular endothelial growth factor: A multifunctional angiogenic cytokine By L. F. Brown, et al. Angiostatin: An endogenous inhibitor of angiogenesis and of tumor growth By M. S. O'Reilly Thrombospondin as a regulator of angiogenesis By L. A. DiPietro Regulation of capillary formation by laminin and other components of the extracellular matrix By D. S. Grant, H. K. Kleinman Hypoxia and angiogenesis in experimental tumor models: Therapeutic implications By S. Rockwell, et al. The role of vascular cell integrins {-63}actual symbol not reproducible in angiogenesis By J. A. Varner Role of fibrin and plasminogen activators in repair-associated angiogenesis: In vitro studies with human endothelial cells By V. W. M. van Hinsbergh, et al. Tumor angiogenesis: Functional similarities with tumor invasion By W. G. Stetler-Stevenson et al. Control of angiogenesis by the pericycte: Molecular mechanisms and significance By K. K. Hirschi, P. A. D'Amore Other drugs that may act in a manner similar to Angiostatin include squalamine derived from shark tissue (Magainin Pharmaceuticals Inc). These drugs belong to chemical Amino Acid Mimetics and Peptidomimetics class. A book on this topic is Advances in Amino Acid Mimetics and Peptidomimetics,by Andrew Abell (Editor) Yet another class of chemicals that may yield significant breakthroughs are the Matrix Metalloproteinases. A book on these is: Matrix Metalloproteinases, by William C. Parks, Robert P. Mecham Other relevant books for professionals include: Tamoxifen : Molecular Basis of Use in Cancer Treatment and Prevention, by Helen Wiseman Cancer Therapy : Differentiation, Immunomodulation and Angiogenesis (NATO Asi Series H : Cell Biology, Vol 75) ,by Natale D'Alessandro A Commotion in the Blood : Life, Death, and the Immune System (The Sloan Technology Series), by Stephen S. Hall The Radiation Biology of the Vascular Endothelium,by David B. Rubin (Editor) Clinical Endocrine Oncology, by Richard Sheaves (Contributor), Paul J. Jenkins (Editor), John A. H. Wass (Editor) Differential Diagnosis of Tumors and Tumor-Like Lesions of Bones and Joints,by Adam, Md. Greenspan, Wolfgang, Md. Remagen The Biological Basis of CancerRobert McKineell The Molecular Basis of Cancer Cancer Peter B. Farmer, John M. Walker Biologic Therapy of Cancer by Vincent T. Devita (Editor), Samuel Hellman, Steven A. Rosenberg (Editor), DeVita Hellman For the layperson, there are many interesting, motivating and at times inspirational books. We recommend you consider these for your personal library Making Miracles Happen , by Gregory White Smith, Steven W. Naifeh, Fredrica S. Friedman (Editor) Curing Cancer: The Story of the Men and Women Unlocking the Secrets of Our Deadliest Illness, by Michael Waldholz Living Beyond Limits , by David Spiegel The Activist Cancer Patient : How to Take Charge of Your Treatment , by Beverly Zakarian, Ezra M., MD Greenspan (Introduction) Informed Decisions : The Complete Book of Cancer Diagnosis, Treatment, and Recovery , by Gerald P., MD Murphy (Editor), Lois B. Morris (Editor), Dianne Lange About Cancer (For Your Information) , by Cynthia Moritz
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